Acevedo, N., B. Davis, C. M. Schaeberle, C. Sonnenschein and A. M. Soto. 2013. Perinatally administered bisphenol A as a potential mammary gland carcinogen in rats. Environ. Health Perspect. 121: 1040–1046.
PubMed Link
Ahlgren, S. C., V. Thakur and M. Bronner-Fraser. 2002. Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol. Proc. Natl. Acad. Sci. USA 99: 10476–10481.
PubMed Link
Anway, M. D. and M. K. Skinner. 2006. Epigenetic transgenerational actions of endocrine disruptors. Endocrinology 147: S43–S49.
PubMed Link
Anway, M. D., A. S. Cupp, M. Uzumcu and M. K. Skipper. 2005. Epigenetic transgeneration effects of endocrine disruptors and male fertility. Science 308: 1466–1469.
PubMed Link
Auerbach, R. 1961. Genetic control of thymus lymphoid differentiation. Proc. Natl. Acad. Sci. USA. 47: 1175–1181.
PubMed Link
Aviv, R. 2014. A valuable reputation. The New Yorker, February 10, 2014.
Link
Barbash, J. E., G. P. Thelin, D. W. Kolpin and R. J. Gilliom. 2001. Major herbicides in ground water: Results from the National Water-Quality Assessment. J. Environ. Qual. 30: 831–845.
PubMed Link
Battaglin, W. A., E. T. Furlong, M. R. Burkhardt and C. J. Peter. 2000. Occurrence of sulfonylurea, sulfonamide, imidazolinone, and other herbicides in rivers, reservoirs, and ground water in the midwestern United States 1998. Sci. Total Environ. 248: 123–133.
PubMed Link
Bell, S. E. 1986. A new model of medical technology development: A case study of DES. Sociol. Health Care 4: 1–32.
Bellus, G. A., K. Gaudenz, E. H. Zackai, L. A. Clarke, J. Szabo, C. A. Francomano and M. Muenke. 1996. Identical mutations in three fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes.Nature Genet. 14: 174–176.
PubMed Link
Benson, G. V., H. Lim, B. C. Paria, I. Satokata, S. K. Dey and R. Maas. 1996. Mechanisms of female infertility in Hoxa-10 mutant mice: Uterine homeosis versus loss of maternal Hoxa-10 expression. Development 122: 2687–2696.
PubMed Link
Berdasco, M. and 9 others. 2009. Epigenetic inactivation of Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proc. Natl. Acad. Sci. USA 106: 21830–21835.
PubMed Link
Bergeron, J. M., D. Crews and J. A. MacLachlan. 1994. PCBs as environmental estrogens: Turtle sex determination as a biomarker of environmental contamination. Environ. Health Perspect. 102: 780–781.
PubMed Link
Bergeron, J. M., E. Willingham, C. T. Osborn III, T. Rhen and D. Crews. 1999. Developmental synergism of steroidal estrogens in sex determination. Environ. Health Perspect. 107: 93–97.
PubMed Link
Berman, D. M. and 10 others. 2002. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297: 1559–1561.
PubMed Link
Berman, D. M. and 10 others. 2003. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumors. Nature 425: 846–851.
PubMed Link
Bissell, M. J., D. C. Radisky, A. Rizki, V. M. Weaver and O. W. Petersen. 2002. The organizing principle: Microenvironmental influences in the normal and malignant breast. Differentiation 70: 537–546.
PubMed Link
Blumenstyk, G. 2003. The story of Syngenta and Tyrone Hayes at UC Berkeley: A Berkeley scientist says a corporate sponsor tried to bury his unwelcome findings and then buy his silence. Chron. Higher Ed. 50(10) 31 October.
Link
Booth, B. W., Boulanger, C. A., Anderson, L. H. and G. H. Smith. 2011.The normal mammary microenvironment suppresses the tumorigenic phenotype of mouse mammary tumor virus-neu-transformed mammary tumor cells. Oncogene30: 679–689.
PubMed Link
Boué, A., J. Boué and A. Gropp. 1985. Cytogenetics of pregnancy wastage. Adv. Hum. Genet. 14: 1–57.
PubMed Link
Boutin, E. L. and G. R. Cunha. 1997. Estrogen-induced epithelial proliferation and cornification are uncoupled in sinus vaginal epithelium associated with uterine stroma. Differentiation 62: 171–178.
PubMed Link
Cagen, S. Z. and 10 others. 1999. Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A. Toxicol. Sci. 50: 36–44.
PubMed Link
Calafat, A. M., Z. Kuklenyik, J. A. Reidy, S. P. Caudill, J. Ekong and L. L. Needham. 2005. Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population. Environ. Health Perspect. 113: 391–395.
PubMed Link
Carson, R. 1962. Silent Spring. Houghton Mifflin, New York.
Carta, L. and D. Sassoon. 2004. Wnt7a is a suppressor of cell death in the female reproductive tract and is required for postnatal and estrogen-mediated growth. Biol. Reprod. 71: 444–454.
PubMed Link
Chang, K. T. and K. T. Min. 2009. Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: Implications for Down syndrome. Proc. Natl. Acad. Sci. USA 106: 17117–17122.
PubMed Link
Chapel Hill Consensus. 2007. Statement from BPA expert panel: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod. Toxicol. 24: 131–138.
PubMed Link
Chavez, S. L. and 8 others. 2012. Dynamic blastomere behaviour reflects human embryo ploidy by the four-cell stage. Nature Commun. 3: 1251.
PubMed Link
Chen J. and 6 others. 2012. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 488: 522–526.
PubMed Link
Chen, S. Y., D. B. Dehart and K. K. Sulik. 2004. Protection from ethanol-induced limb malformations by the superoxide dismutase/catalase mimetic, EUK-134.FASEB J. 18: 1234–1236.
PubMed Link
Chrisman, K., R. Kenney, J. Comin, T. Thal, L. Suchoki, Y. G. Yueh and D. F. Gardner. 2004. Gestational ethanol exposure disrupts the expression of Fgf8 and Sonic hedgehog during limb patterning. Birth Def. Res. A 70: 163–171.
PubMed Link
Clarren, S. K. 1986. Neuropathology in the fetal alcohol syndrome. In J. R. West (ed.), Alcohol and Brain Development. Oxford University Press, New York.
Cohlan, S. Q. 1953. Excessive intake of vitamin A as a cause of congenital anomalies in the rat. Science 117: 535–537.
PubMed Link
Colburn, T., C. Kwiatkowski, K. Schultz and M. Bachran. 2011. Natural gas operations fro a public health perspective. Human Ecol. Risk Assess. 17: 1039–1056.
Link
Colborn, T., D. Dumanoski and J. P. Myers. 1997. Our Stolen Future. Dutton, New York.
Colborn, T., F. S. vom Saal and A. M. Soto. 1993. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Perspect. 101: 378–384.
PubMed Link
Coleman, H., J. Nabekura and J. W. Lichtman. 1997. Alterations in synaptic strength preceding axon withdrawal. Science 275: 356–361.
PubMed Link
Dalton, R. 2002. Frogs put in the gender blender by America’s favourite herbicide. Nature 416: 665–666.
PubMed Link
Davis, W. L., L. A. Crawford, O. Cooper, G. R. Farmer, D. Thomas and B. L. Freeman. 1990. Ethanol induces the generation of reactive free radicals by neural crest cells in culture. J. Craniofac. Genet. Dev. Biol. 10: 277–293.
PubMed Link
de Soysa, T. Y. and 13 others. 2012. Macondo crude oil from the Deepwater Horizon oil spill disrupts specific developmental processes during zebrafish embryogenesis. BMC Biol. 10: 40.
PubMed Link
DOE (U.S. Department of Energy). 2009. State Oil and Natural Gas Regulations Designed to Protect Water Resources, May 2009.
Link
Dorris, M. 1989. The Broken Cord. Harper and Row, New York.
Durando, M., L. Kass, J. Piva, C. Sonnenschein, A. M. Soto, E. H Luque and M. Muñoz-de-Toro. 2007. Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats. Environ. Health Perspect. 115: 80–86.
PubMed Link
Dwyer, J. B., R. S. Broide and F. M. Leslie. 2008. Nicotine and brain development. Birth Def. Res. C Embryol. Today 84: 30–44.
PubMed Link
Edmonds, D. K., K. S. Lindsay, J. F. Miller, E. Williamson and P. J. Wood. 1982. Early embryonic mortality in women. Fertil. Steril. 38: 447–453.
PubMed Link
El Hallani, S. and 12 others. 2010. A new alternative mechanism in glioblastoma vascularization: Tubular vasculogenic mimicry. Brain 133(Pt 4): 973–982.
PubMed Link
Elton, T. S., S. E. Sansom and M. M. Martin. 2010. Trisomy-21 gene dosage overexpression of miRNAs results in the haploinsufficiency of specific target proteins. RNA Biol. 7: 540–547.
PubMed Link
Epstein, C. 2008. Human malformations and their genetic basis. In C. Epstein, R. P. Erickson and A. Wynshaw-Boris, Inborn Errors of Development: The Molecular Basis of Clinical Disorders of Morphogenesis, 2nd Ed. Oxford University Press, New York, pp. 3–8.
Finer, L. B. and M. R. Zolna. 2011. Unintended pregnancy in the United States: Incidence and disparities, 2006. Contraception 84: 478–485.
PubMed Link
Flentke, G. R., A. Garic, E. Amberger, M. Hernandez and S. M. Smith. 2011. Calcium-mediated repression of b-catenin and its transcriptional signaling mediates neural crest cell death in an avian model of fetal alcohol syndrome.Birth Defects Res. A: Clin. Mol. Teratol. 91: 591–602.
PubMed Link
Fontana, J. A. and A. K. Rishi. 2002. Classical and novel retinoids: Their targets in cancer therapy. Leukemia 16: 463–472.
PubMed Link
Freire-Maia, N. 1975. A heterozygote expression of a “recessive” gene. Hum. Hered. 25: 302–304.
PubMed Link
Gilbert, S. F. and D. Epel. 2015. Ecological Developmental Biology: The Environmental Regulation of Development, Health, and Evolution, 2nd Ed. Sinauer Associates, Sunderland, MA.
Gilbert, S. F. and E. Jorgensen. 1998. Wormwholes: A commentary on K. Schaffner's "Genes, behavior, and developmental emergentism." Philos. Sci. 65: 259–266.
Link
Gioiosa, L., P. Palanza, S. Parmigiani and F. S. Vom Saal. 2015. Risk evaluation of endocrine-disrupting chemicals: Effects of developmental exposure to low doses of bisphenol A on behavior and physiology in mice (Mus musculus). Dose Response 13: 1559325815610760.
PubMed Link
Giroud, A. and M. Martinet. 1959. Teratogenese pur hypervitaminose A chez le rat, la souris, le cobaye, et le lapin. Arch. Fr. Pediatr. 16: 971–980.
Gottlieb, G. 2003. On making behavioral genetics truly developmental. Hum. Dev. 46: 337–355.
Link
Goulding, E. H. and R. M. Pratt. 1986. Isotretinoin teratogenicity in mouse whole embryo culture. J. Craniofac. Genet. Dev. Biol. 6: 99–112.
PubMed Link
Grüneberg, H. 1938. An analysis of the “pleiotropic” effects of a new lethal mutation in the rat (Mus norwegicus). Proc. R. Soc. Lond. B 125: 123–144.
Green, M. L., A. V. Singh, Y. Zhang, K. A. Nemeth, K. K. Sulik and T. B. Knudsen. 2007. Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome. Dev. Dyn. 236: 613–631.
PubMed Link
Grignani, F. and 14 others. 1998. Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature 391: 815–818.
PubMed Link
Guerrero-Bosagna, C., M. Settles, B. Lucker and M. K. Skinner. 2010. Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. PLoS One 5(9) pii: e13100.
PubMed Link
Gupta, P. B., C. L. Chaffer and R. A. Weinberg. 2009. Cancer stem cells: Mirage or reality? Nature Medicine 15: 1010–1012.
PubMed Link
Hadorn, E. 1955. Letalfaktoren in ihrer Bedeutung für Erbpathologie und Genphysiologie der Entwicklung. Thieme Verlag, Stuttgart.
Hamer, H. 2010. Acreage. National Agricultural Statistics Board Annual Report. United States Department of Agriculture.
Hanahan, D. and R. A. Weinberg. 2000. The hallmarks of cancer. Cell 100: 57–70.
PubMed Link
Hansen, L. A., C. C. Sigman, F. Andreola, S. A. Ross, G. J. Kelloff and L. M. De Luca. 2000. Retinoids in chemoprevention and differentiation therapy.Carcinogenesis 21: 1271–1279.
PubMed Link
Hayes, T. B. and 10 others. 2010. Atrazine induces complete feminization and chemical castration in male African clawed frogs (Xenopus laevis). Proc. Natl. Acad. Sci. USA 107: 4612–4617.
PubMed Link
Hayes, T. B. and 21 others. 2011. Demasculinization and feminization of male gonads by atrazine: consistent effects across vertebrate classes. J. Steroid Biochem. Mol. Biol. 127: 64–73.
PubMed Link
Hayes, T. B., A. Collins, M. Lee, M. Mendoza, N. Noriega, A. Stuart and A. Vonk. 2002a. Hermaphroditic, demasculinized frogs after exposure to the herbicide atrazine at low ecologically relevant doses. Proc. Natl. Acad. Sci. USA 99: 5476–5480.
PubMed Link
Hayes, T., K. Haston, M. Tsui, A. Hoang, C. Haeffele and A. Vonk. 2002b. Herbicides: Feminization of male frogs in the wild. Nature 419: 895–896.
PubMed Link
Hayes, T., K. Haston, M. Tsui, A. Hoang, C. Haeffele and A. Vonk. 2003. Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): Laboratory and field evidence. Envir. Health Perspec. 111: 568–575.
PubMed Link
Hendrix, M. J., E. A. Seftor, R. E. Seftor, J. Kasemeier-Kulesa, P. M. Kulesa and L. M. Postovit. 2007. Reprogramming metastatic tumour cells with embryonic microenvironments. Nature Rev. Cancer 7: 246–255.
PubMed Link
Hoffman, L. M. and W. M. Kulyk. 1999. Alcohol promotes in vitro chondrogenesis in embryonic facial mesenchyme. Int. J. Dev. Biol. 43: 167–74.
PubMed Link
Holliday, R. 2005. DNA methylation and epigenotypes. Biochemistry 70: 500–504.
PubMed Link
Hoover, R. N. and 18 others. 2011. Adverse health outcomes in women exposed in utero to diethylstilbestrol. New Engl. J. Med. 365: 1304–1314.
PubMed Link
Howdeshell, K. L., A. K. Hotchkiss, K. A. Thayer, J. G. Vandenbergh and F. S. vom Saal. 1999. Exposure to bisphenol A advances puberty. Nature 401: 763–764.
PubMed Link
Howdeshell, K. L. and F. S. vom Saal. 2000. Developmental exposure to bisphenol A: Interaction with endogenous estradiol during pregnancy in mice. Amer. Zool. 40: 429–437.
Link
Howdeshell, K., L. and 7 others. 2003. Bisphenol A is released from used polycarbonate animal cages into water at room temperature. Envir. Health Persp. 111: 1180–1187.
PubMed Link
Hunt, P. A. and 7 others. 2012. Bisphenol A alters early oogenesis and follicle formation in the fetal ovary of the rhesus monkey. Proc. Natl. Acad. Sci. USA109: 17525–17530.
PubMed Link
Hunt, P. A. and 8 others. 2003. Bisphenol A exposure causes meiotic aneuploidy in the female mouse. Curr. Biol. 13: 546–553.
PubMed Link
Ikezuki, Y., O. Tsutsumi, Y. Tahai, Y. Kamzi and Y. Taketa. 2002. Determination of bisphenol A concentrations in human biological fluids reveals significant prenatal exposure. Human Reprod. 17: 2839–2841.
PubMed Link
Illmensee, K. and B. Mintz. 1976. Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts. Proc. Natl. Acad. Sci. USA 73: 549–553.
PubMed Link
Jablonka, E. and G. Raz. 2009. Transgenerational epigenetic inheritance: Prevalence, mechanisms, and implications for the study of heredity and evolution. Q. Rev. Biol. 84: 131–176.
PubMed Link
Johnston, M. C., K. K. Sulik, W. S. Webster and B. L. Jarvis. 1985. Isotretinoin embryopathy in a mouse model: Cranial neural crest involvement. Teratology 31: 26A.
Jones, K. L. and D. W. Smith. 1973. Recognition of the fetal alcohol syndrome in early infancy. Lancet 302: 999–1001.
PubMed Link
Kabir, E. R., M. S. Rahman and I. Rahman. 2015. A review on endocrine disruptors and their possible impacts on human health. Environ. Toxicol. Pharmacol. 40: 241–58.
PubMed Link
Kasemeier-Kulesa, J. C. and 6 others. 2008. Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment. Dev. Dyn. 237: 2657–2666.
PubMed Link
Kassotis, C. D., D. E. Tillitt, J. W. Davis, A. M. Hormann and S. C. Nagel. 2014. Estrogen and androgen receptor activities of hydraulic fracturing chemicals and surface and ground water in a drilling-dense region. Endocrinology 155: 897–907.
PubMed Link
Kaufman C. K. and 17 others. A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science 351: 464.
PubMed Link
Kilfoil, M. L., P. Lasko and E. Abouheif. 2009. Stochastic variation: From single cells to superorganisms. Hum. Front. Sci. Prog. J. 3: 379–385.
PubMed Link
Kitajewsky, J. and D. Sassoon. 2000. The emergence of molecular gynecology: Homeobox and Wnt genes in the female reproductive tract. BioEssays 22: 902–910.
PubMed Link
Kochhar, D. M., J. D. Penner and C. Tellone. I. 1984. Comparative teratogenic activities of two retinoids: Effects on palate and limb development. Teratogen. Carcinogen. Mutagen. 4: 377–387.
PubMed Link
Korbel, J. O. and 30 others. 2009. The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies.Proc. Natl. Acad. Sci. USA 106: 12031–12036.
PubMed Link
Kotch, L. E., S.-Y. Chen and K. K. Sulik. 1995. Ethanol-induced teratogenesis: Free radical damage as a possible mechanism. Teratology 52: 128–136.
PubMed Link
Krishnan, A. V., P. Starhis, S. F. Perlmuth, I. Tokes and D. Feldman. 1993. Bisphenol-A: An estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinol. 132: 2279–2286.
PubMed Link
Kubo, K., O. Arai, M. Omura, R. Watanabe, R. Ogata and S. Aou. 2003. Low dose effects of bisphenol A on sexual differentiation of the brain and behavior in rats. Neurosci. Res. 45: 345–356.
PubMed Link
Kulp, L. and J. Kulp. 2000. The Best I Can Be: Living with Fetal Alcohol Syndrome-Effects. Better Endings/New Beginnings Press.
Lammer, E. J. and 11 others. 1985. Retinoic acid embryopathy. N. Engl. J. Med.313: 837–841.
PubMed Link
Langlois, V. S., A. C. Carew, B. D. Pauli, M. G. Wade, G. M. Cooke and V. L. Trudeau. 2010. Low levels of the herbicide atrazine alter sex ratios and reduce metamorphic success in Rana pipiens tadpoles raised in outdoor mesocosms.Environ. Health Perspect. 118: 552–557.
PubMed Link
Lapidot, T. and 9 others. 1994. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367: 645–648.
PubMed Link
Lathi, R. B., C. A. Liebert, K. F. Brookfield, J. A. Taylor, F. S. vom Saal, V. Y. Fujimoto and V. L. Baker. 2014. Conjugated bisphenol A in maternal serum in relation to miscarriage risk. Fertil. Steril. 102: 123–128.
PubMed Link
Layton, L. and C. Lee. 2008. Canada bans BPA from baby bottles. Washington Post, April 19, p. A3.
Lee, H. Y., A. L. Inselman, J. Kanungo and D. K. Hansen. 2012. Alternative models in developmental toxicology. Syst. Biol. Reprod. Med. 58: 10–22.
PubMed Link
Lemoine, E. M., J. P. Harousseau, J. P. Borteyru and J. C. Menuet. 1968. Les enfants de parents alcoholiques: Anomalies observées. Oest. Med. 21: 476–482.
Lenz, W. 1962. Thalidomide and congenital abnormalities. Lancet 1: 45. (First reported at a 1961 symposium.)
Ma, L., G. V. Benson, H. Lim, S. K. Dey and R. Maas. 1998. Abdominal B (AbdB) Hoxa genes: Regulation in adult uterus by estrogen and progesterone and repression in Müllerian duct by the synthetic estrogen diethylstilbestrol (DES).Dev. Biol. 197: 141–154.
PubMed Link
Mack, S. C. and 88 others. 2014. Epigenomic alterations define lethal CIMP-positive ependymomas of infancy. Nature 506: 445–450.
PubMed Link
Maffini, M. V., A. M. Soto, J. M. Calabro, A. A. Ucci and C. Sonnenschein. 2004. The stroma as a crucial target in mammary gland carcinogenesis. J. Cell Sci. 117: 1495–1502.
PubMed Link
Mantzouratou, A. and J. D. Delhanty. 2011. Aneuploidy in the human cleavage stage embryo. Cytogenet. Genome Res. 133:141–148.
PubMed Link
Maritz, G. S. and R. Harding. 2011. Life-long programming implications of exposure to tobacco smoking and nicotine before and soon after birth: evidence for altered lung development. Int. J. Environ. Res. Public Health 8: 875–898.
PubMed Link
Markey, C. M., M. A. Coombs, C. Sonnenschein and A. M. Soto. 2003. Mammalian development in a changing environment: Exposure to endocrine disruptors reveals the developmental plasticity of steroid hormone target organs. Evo. Dev. 5: 67–75.
PubMed Link
May, P. A. and J. P. Gossage. 2001. Estimating the prevalence of fetal alcohol syndrome: A summary. Alch. Res. Health 25: 159–167.
PubMed Link
McKenzie, L. M., R. Guo, R. Z. Witter, D. A. Savitz, L. S. Newman and J. L. Adgate. 2014. Birth outcomes and maternal residential proximity to natural gas development in rural Colorado. Environ. Health Perspect. 122: 412–417.
PubMed Link
Miller, C., K. Degenhardt and D. A. Sassoon. 1998. Fetal exposure to DES results in de-regulation of Wnt7a during uterine morphogenesis. Nature Genet.20: 228–230.
PubMed Link
Miller, W. H., Jr. and 7 others. 1992. Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia. Proc. Natl. Acad. Sci. USA 89: 2694–2698.
PubMed Link
Mishra, P. J. and G. Merlino. 2009. MicroRNA reexpression as differentiation therapy in cancer. J. Clin. Invest. 119: 2119–2123.
PubMed Link
Molenaar, P. C., D. I. Boomsma and C. V. Dolan. 1993. A third source of developmental differences. Behav. Genet. 23: 519–524.
PubMed Link
Moore, K. L. and T. N. N. Persaud. 1993. Before We Are Born: Essentials of Embryology and Birth Defects. W. B. Saunders, Philadelphia.
Moroni, M. C., M. A. Viganó and F. Mavilio. 1994. Regulation of human Hoxd-4gene by retinoids. Mech. Dev. 44: 139–154.
PubMed Link
Muñoz-de-Toro, C. M. Markey, P. R. Wadia, E. H. Luque, B. S. Rubin, C. Sonnenschein and A. M. Soto. 2005. Perinatal exposure to bisphenol A alters peripubertal mammary gland development in mice. Endocrinology 146: 4138–4147.
PubMed Link
Murray, T. J., M. V. Maffini, A. A. Ucci, C. Sonenschein and A. M. Soto. 2007. Induction of mammary gland ductal hyperplasias and carcinomia in situ following bisphenol-A exposure. Reprod. Toxicol. 23: 383–390.
PubMed Link
Murray, T. J., M. V. Maffini, A. A. Ucci, C. Sonnenschein and A. M. Soto. 2006. Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure. Reprod. Toxicol. 23: 383–390.
PubMed Link
Myers, J. P. and 35 others. 2009. Why public health agencies cannot depend on good laboratory prctices as a criterion for selecting data: the case of bisphenol A. Environ. Health Perspect. 117: 309–315.
PubMed Link
Newbold, R. R., S. Tyrey, A. F. Haney and J. A. MacLachlan. 1983. Developmentally arrested oviduct: A structural and functional defect in mice following prenatal exposure to diethylstilbestrol. Teratology 27: 417–426.
PubMed Link
Nowak, D., D. Stewart and H. P. Koeffler. 2009. Differentiation therapy of leukemia: Three decades of development. Blood 113: 3655–3665.
PubMed Link
Opitz, J. 1987. Prenatal and perinatal death: The future of developmental pathology. The Farber Lecture. Pediatr. Pathol. 7: 363–394.
PubMed Link
Paganelli, A., V. Gnazzo, H. Acosta, S. L. López and A. E. Carrasco. 2010. Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling. Chem. Res. Toxicol. 23: 1586–1595.
PubMed Link
Palanza, P., K. L. Howdeshell, S. Parmigiani and F. S. vom Saal. 2002. Exposure to a low dose of bisphenol-A during fetal life or in adulthood alters maternal behavior in mice. Environ. Health Perspect. (Suppl.) 110: 415–422.
PubMed Link
Palmlund, I. 1996. Exposure to a xenoestrogen before birth: The diethylstilbestrol experience. J. Psychosom. Obstet. Gynecol. 17: 71–84.
PubMed Link
Pierce, G. B. 1974. Neoplasms, differentiations, and mutations. Am. J. Pathol. 77: 103–118.
PubMed Link
Pierce, G. B. and C. Wallace. 1971. Differentiation of malignant to benign cells.Cancer Res. 31: 127.
PubMed Link
Pierce, G. B., R. Shikes and L. M. Fink. 1978. Cancer: A Problem of Development. Prentice-Hall, Englewood Cliffs, NJ.
Postovit, L. M. and 8 others. 2008. Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc. Natl. Acad. Sci. USA 105: 4329–4334.
PubMed Link
Raj, A. and A. van Oudenaarden. 2008. Nature, nurture, or chance: Stochastic gene expression and its consequences. Cell 135: 216–226.
PubMed Link
Ramanathan, R., M. F. Wilkemeyer, B. Mittel, G. Perides and M. E. Charness. 1996. Alcohol inhibits cell-cell adhesion mediated by human L1. J. Cell Biol.133: 381–390.
PubMed Link
Rappaport, S. M. and M. T. Smith. 2010. Environment and disease risks. Science330: 460–461.
PubMed Link
Ricci-Vitiani, L. and 10 others. 2010. Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells. Nature 468: 824–828.
PubMed Link
Robboy, S. J., R. H. Young and A. L. Herbst. 1982. Female genital tract changes related to prenatal diethylstilbestrol exposure. In A. Blaustein (ed.), Pathology of the Female Genital Tract, 2nd Ed. Springer-Verlag, New York, pp. 99–118.
Rubin, L. L. and F. J. de Sauvage. 2006. Targeting the Hedgehog pathway in cancer. Nature Rev. Drug Discov. 5: 1026–1033.
PubMed Link
Ruvinsky, A. 2009. Genetics and Randomness. Taylor and Francis, London.
Sachs, L. 1978. Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukemias. Nature 274: 535–539.
PubMed Link
Schönfelder, G., W. Wittfoht, H. Hopp, C. E. Talsness, M. Paul and I. Chahoud. 2002. Parent bisphenol A accumulation in the human maternal-fetal-placental unit. Environ. Health Perspect. 110: A703–A707.
PubMed Link
Schepers, A. G. and 6 others. 2013. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 337: 730-–735.
PubMed Link
Singh, A. and J. Settleman. 2010. EMT, cancer stem cells, and drug resistance: An emerging axis of evil in the war on cancer. Oncogene 29: 4741–4751.
PubMed Link
Skinner, M. K., M. Manikkam and C. Guerrero-Bosagna. 2010. Epigenetic transgenerational actions of endocrine disruptors. Reprod. Toxicol. 31: 337–343.
PubMed Link
Smith, G. D. 2011. Epidemiology, epigenetics and the “Gloomy Prospect”: Embracing randomness in population health research and practice. Int. J. Epidemiol. 40: 537–562.
PubMed Link
Sonnenschein, C. and A. M. Soto. 1999. The Society of Cells: Cancer and the Control of Cell Proliferation. Bios Publishers, Oxford.
Sonnenschein, C. and A. M. Soto. 2000. Somatic mutation theory of carcinogenesis: Why it should be dropped and replaced. Mol. Carconogen. 29: 205–211.
PubMed Link
Stevens, L. C. and C. C. Little. 1953. Spontaneous testicular teratomas in an inbred strain of mice. Proc. Natl. Acad. Sci. USA 40: 1080–1087.
PubMed Link
Stewart, T. A. and B. Mintz. 1981. Successive generations of mice produced from an established culture line of euploid teratocarcinoma cells. Proc. Natl. Acad. Sci. USA 78: 6314–6318.
PubMed Link
Stockholm, D. and 8 others. 2010. Bistable cell fate specification as a result of stochastic fluctuations and collective spatial cell behaviour. PLoS One 5: e14441.
PubMed Link
Stouder, C. and A. Paoloni-Giacobino. 2010. Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm. Reproduction 139: 373–379.
PubMed Link
Streissguth, A. P. and R. A. LaDue. 1987. Fetal alcohol: Teratogenic causes of developmental disabilities. In S. R. Schroeder (ed.), Toxic Substances and Mental Retardation. American Association of Mental Deficiency, Washington, DC, pp. 1–32.
Studer, M., H. Pöpperl, H. Marshall, A. Kuroiwa and R. Krumlauf. 1994. Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1.Science 265: 1728–1732.
PubMed Link
Sulik, K. K. 2005. Genesis of alcohol-induced craniofacial dysmorphism. Exp. Biol. Med. 230: 366–375.
PubMed Link
Susiarjo, M., I. Sasson, C. Mesaros, and M. S. Bartolomei. 2013. Bisphenol A exposure disrupts genomic imprinting in the mouse. PLoS Genet. 9: e1003401.
PubMed Link
Swan, S. and 8 others. 2003. Semen quality in relation to biomarkers of pesticide exposure. Environ. Health Perspect. 111: 1478–1484.
PubMed Link
Taulli, R. and 7 others. 2009. The muscle-specific microRNA miR-206 blocks human rhabdomyosarcoma growth in xenotransplanted mice by promoting myogenic differentiation. J. Clin. Invest. 119: 2366–2378.
PubMed Link
Tharp A.P., M. V. Maffini, P. A. Hunt, C. A. VandeVoort, C. Sonnenschein and A. M. Soto. 2012. Bisphenol A alters the development of the rhesus monkey mammary gland. Proc. Natl. Acad.Sci. USA 109: 8190–8195.
PubMed Link
Thayer, S. P. and 13 others. 2003. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425: 851–856.
PubMed Link
Tian, H. and 6 others. 2009. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc. Natl. Acad. Sci. USA 106: 4254–4259.
PubMed Link
Tiberio, G. 1994. MZ female twins discordant for X-linked diseases: A review. Acta Genet. Med. Gemellol. 43: 207–214.
PubMed Link
Timms, B. G. K. Howdeshell, L. Barton, S. Bradley, C. A. Richter and F. S. vom Saal. 2005. Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra. Proc. Natl. Acad. Sci. USA102: 7014–7019.
PubMed Link
Valenzuela, N., J. Neuwald and R. Literman. 2013. Transcriptional evolution underlying vertebrate sexual development. Dev. Dyn. 242: 307–319.
PubMed Link
Valleix, S., C. Vinciguerra, J. M. Lavergne, M. Leuer, M. Delpech and C. Negrier. 2002. Skewed X-chromosome inactivation in monochorionic diamniotic twin sisters results in severe and mild hemophilia A. Blood 100: 3034–3036.
PubMed Link
Vandenberg, L. N. and 11 others. 2012. Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses. Endocr. Rev. 33: 378–455.
PubMed Link
van Heyningen, V. 2000. Gene games of the future. Nature 408: 769–771.
Vogt, G., M. Huber, M. Thiemann, G. van den Boogaart, O. J. Schmitz and C. D. Schubart. 2008. Production of different phenotypes from the same genotype in the same environment by developmental variation. J. Exp. Biol. 211: 510–523.
PubMed Link
vom Saal, F. S. 2000. Very low doses of bisphenol A and other estrogenic chemicals alters development in mice. Endocrine Disruptors and Pharmaceutical Active Compounds in Drinking Water Workshop.
Link
vom Saal, F. S. and 37 others. 2007. Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals, and potential to impact human health at current levels of exposure. Reprod. Toxicol.24: 131–138.
PubMed Link
vom Saal, F. S. and 7 others. 1998. A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior. Toxicol. Ind. Health 14: 239–260.
PubMed Link
vom Saal, F. S. and 9 others. 1997. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc. Natl. Acad. Sci. USA 94: 2056–2061.
PubMed Link
vom Saal, F. S. and C. Hughes. 2005. An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment. Envir. Health Perspec. 113: 926–933.
PubMed Link
von Goetz, N., M. Wormuth, M. Scheringer and K. Hungerbühler. 2010. Bisphenol A: How the most relevant exposure sources contribute to total consumer exposure. Risk Anal. 30: 473–487.
PubMed Link
Wagner, E. F. 2016. Fibroblasts for all seasons. Nature 530: 42–43.
PubMed Link
Walker, D. M. and A. C. Gore. 2011. Transgenerational neuroendocrine disruption of reproduction. Nature Rev. Endocrinol. 7: 197–207.
PubMed Link
Wang, R. and 9 others. 2010. Glioblastoma stem-like cells give rise to tumour endothelium. Nature 468: 829–833.
PubMed Link
Wang, X. and 21 others. 2013. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nature Med. 19: 473–480.
PubMed Link
Warren, K. R. and T.-K. Li. 2005. Genetic polymorphisms: Impact on the risk of fetal alcohol spectrum disorders. Birth Def. Res. A. 73: 195–203.
PubMed Link
Weaver, V. M., O. W. Petersen, F. Wang, C. A. Larabell, P. Briand, C. Damsky and M. J. Bissell. 1997. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin-blocking antibodies. J. Cell Biol. 137: 231– 245.
PubMed Link
Webb, E., S. Bushkin-Bedient, A. Cheng, C. D. Kassotis, V. Balise and S. C. Nagel. 2014. Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations. Rev. Environ. Health 29: 307–318.
PubMed Link
Wetherill, Y. B., C. E. Petse, K. R. Monk, A. Puga and K. E. Knudson. 2002. Xenoestrogen bisphenol-A induces inappropriate androgen receptor activation and mitogenesis in prostatic adenocarcinoma cells. Mol. Cancer Ther. 1: 515–524.
PubMed Link
Wild, C. P. 2005. Complementing the genome with an “exposome”: The outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epid. Biomarkers Prev. 14: 1847.
PubMed Link
Winter, R. M. 1996. Analyzing human developmental anomalies. BioEssays 18: 965–971.
PubMed Link
Wolf, U. 1995. The genetic contribution to the phenotype. Hum. Genet. 95: 127–148.
PubMed Link
Wolf, U. 1997. Identical mutations and phenotypic variation. Hum. Genet. 100: 305–321.
PubMed Link
Wozniak, J. R. and R. L. Muetzel. 2011. What does diffusion tensor imaging reveal about the brain and cognition in fetal alcohol spectrum disorders?Neuropsychol Rev. 21: 133–147.
PubMed Link
Wright, S. 1920. The relative importance of heredity and environment in determining the piebald pattern of guinea pigs. Proc. Nat. Acad. Sci. USA 6: 320–332.
PubMed Link
Yauch, R. L. and 14 others. 2008. A paracrine requirement for Hedgehog signalling in cancer. Nature 455: 406–410.
PubMed Link
Yauch, R. L. and 17 others. 2009. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 326: 572–574.
PubMed Link
Zhao, C. and 13 others. 2009. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 458: 776–779.
PubMed Link
Zhou, W., Y. Tan, D. J. Anderson, E. M. Crist, H. Ruohola-Baker, S. J. Salipante and M. S. Horwitz. 2013. Use of somatic mutations to quantify random contributions to mouse development. BMC Genomics 14: 39.
PubMed Link