Alvarez, I. S. and G. C. Schoenwolf. 1992. Expansion of surface epithelium provides the major extrinsic force for bending of the neural plate. J. Exp. Zool. 261: 340–348.
PubMed Link
Anderson, D. D., C. F. Woeller, E. P. Chiang, B. Shane and P. J. Stover. 2012. Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis. J. Biol. Chem. 287: 7051–7062.
PubMed Link
Archer, T. C., J. Jin and E. S. Casey. 2011. Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis. Dev. Biol. 350: 429–40.
PubMed Link
Artama, M., A. Auvinen, T. Raudaskoski, I. Isojärvi, and J. Isojärvi. 2005. Antiepileptic drug use of women with epilepsy and congenital malformations in offspring. Neurology 64: 1874–1878.
PubMed Link
Balaskas, N. and 7 others. 2012. Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. Cell 148: 273–284.
PubMed Link
Balinsky, B. I. 1975. Introduction to Embryology, 4th Ed. Saunders, Philadelphia.
Bassuk, A. G. and Z. Kibar. 2009. Genetic basis of neural tube defects. Semin. Pediatr. Neurol. 16: 101–110.
PubMed Link
Briscoe, J. and S. Small. 2015. Morphogen rules: Design principles of gradient-mediated embryo patterning. Development 142: 3996–4009.
PubMed Link
Briscoe, J., L. Sussel, P. Serup, D. Hartigan-O’Connor, T. M. Jessell, J. L. R. Rubenstein and J. Ericson. 1999. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signaling. Nature 398: 622–627.
PubMed Link
Bu, P., Y. A. Evrard, G. Lozano, and S. Y. R. Dent. 2007. Loss of Gcn5 acetyltransferase activity leads to neural
tube closure defects and exencephaly in mouse embryos. Mol. Cell. Biol. 27: 3405–3416.
PubMed Link
Cambray, N. and V. Wilson. 2007. Two distinct sources for a population of maturing axial progenitors. Development 134: 2829–2840.
PubMed Link
Catala, M., M.-A. Teillet and N. M. Le Douarin. 1995. Organization and development of the tailbud analyzed with the quail-chick chimaera system.Mech. Dev. 51: 51–65.
PubMed Link
Catala, M., M.-A. Teillet, E. M. De Robertis and N. M. Le Douarin. 1996. A spinal cord fate map in the avian embryo: While regressing, Hensen’s node lays down the notochord and floor plate thus joining the spinal cord lateral walls.Development 122: 2599–2610.
PubMed Link
Catela, C., M. M. Shin, and J. S. Dasen. 2015. Assembly and function of spinal circuits for motor control. Annu. Rev. Cell Dev. Biol. 31: 669–698.
PubMed Link
Centers for Disease Control. 1992. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. Morb. Mortal. Wkly. Rep. 41: 1–7.
PubMed Link
Chapman, D. L. and V. E. Papaioannou. 1998. Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature 391: 695–697.
PubMed Link
Chiang, C., Y. Litingtung, E. Lee, K. E. Young, J. L. Cordoen, H. Westphal and P. A. Beachy. 1996. Cyclopia and axial patterning in mice lacking sonic hedgehoggene function. Nature 383: 407–413.
PubMed Link
Cohen, M., A. Kicheva, A. Ribeiro, R. Blassberg, K. M. Page, C. P. Barnes, and J. Briscoe. 2015. Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms. Nat. Commun. 6: 6709.
PubMed Link
Czeizel, A. E. and I. Dudás. 1992. Prevention of first occurrence of neural tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 327: 1832–1835.
PubMed Link
Dady, A., E. Havis, V. Escriou, M. Catala, and J. L. Duband. 2014. Junctional neurulation: a unique developmental program shaping a discrete region of the spinal cord highly susceptible to neural tube defects. J. Neurosci. 34: 13208–13221.
PubMed Link
Dessaud, E. and 8 others. 2007. Interpretation of the Sonic hedgehog morphogen gradient by a temporal adaptation mechanism. Nature 450: 717–720.
PubMed Link
Detrick, R. J., D. Dickey and C. R. Kintner. 1990. The effects of N-cadherin misexpression on morphogenesis in Xenopus embryos. Neuron 4: 493–506.
PubMed Link
Echelard, Y., D. J. Epstein, B. St.-Jacques, L. Shen, J. Mohler, J. A. McMahon and A. McMahon. 1993. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75: 1417–1430.
PubMed Link
Eom, D. S., S. Amarnath, J. L. Fogel, and S. Agarwala. 2011. Bone morphogenetic proteins regulate neural tube closure by interacting with the apicobasal polarity pathway. Development 138: 3179–3188.
PubMed Link
Eom, D. S., S. Amarnath, J. L. Fogel, and S. Agarwala. 2012. Bone morphogenetic proteins regulate hinge point formation during neural tube closure by dynamic modulation of apicobasal polarity. Birth Defects Res. A: Clin. Mol. Teratol. 94: 804–816.
PubMed Link
Eom, D. S., S. Amarnath, and S. Agarwala. 2013. Apicobasal polarity and neural tube closure. Dev. Growth Differ. 55: 164–172.
PubMed Link
Feil, R., R. A. Waterland, M. F. Fraga, and R. L. Jirtle. 2012. Epigenetics and the environment: Emerging patterns and implications. Nature Rev. Genet. 13: 97–109.
PubMed Link
Fournier-Thibault, C., C. Blavet, A. Jarov, F. Bajanca, S. Thorsteinsdóttir and J. L. Duband. 2009. Sonic hedgehog regulates integrin activity, cadherin contacts, and cell polarity to orchestrate neural tube morphogenesis. J. Neurosci. 29: 12506–12520.
PubMed Link
Fujimori, T., S. Miyatani and M. Takeichi. 1990. Ectopic expression of N-cadherin perturbs histogenesis in Xenopus embryos. Development 110: 97–104.
PubMed Link
Gallera, J. 1971. Primary induction in birds. Adv. Morphogenet. 9: 149–180.
PubMed Link
Gont, L. K., H. Steinbeisser, B. Blumberg and E. M. De Robertis. 1993. Tail formation as a continuation of gastrulation: The multiple cell populations of theXenopus tailbud derive from the late blastopore lip. Development 119: 991–1004.
PubMed Link
Gouti, M., V. Metzis, and J. Briscoe. 2015. The route to spinal cord cell types: A tale of signals and switches. Trends Genet. 31: 282–289.
PubMed Link
Guthrie, S. and A. Lumsden. 1991. Formation and regeneration of rhombomere boundaries in the developing chick hindbrain. Development 112: 221–229.
PubMed Link
Handrigan, G. R. 2003. Concordia discors: Duality in the origin of the vertebrate tail. J. Anat. 202: 255–67.
PubMed Link
Harland, R. 2000. Neural induction. Curr. Opin. Genet. Dev. 10: 357–362.
PubMed Link
Harrington, M. J., E. Hong and R. Brewster. 2009. Comparative analysis of neurulation: First impressions do not count. Mol. Reprod. Dev. 76: 954–965.
PubMed Link
Harris, M. J. and D. M. Juriloff. 2010. An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure. Birth Defects Res. A: Clin. Mol. Teratol. 88: 653–669.
PubMed Link
Hashimoto, H., F. B. Robin, K. M. Sherrard, and E. M. Munro. 2015. Sequential contraction and exchange of apical junctions drives zippering and neural tube closure in a simple chordate. Dev. Cell. 32: 241–255.
PubMed Link
Jacobson, A. G. and J. G. Moury. 1995. Tissue boundaries and cell behavior during neurulation. Dev. Biol. 171: 98–110.
PubMed Link
Jessell, T. M. 2000. Neuronal specification in the spinal cord: Inductive signals and transcriptional codes. Nature Rev. Genet. 1: 20–29.
PubMed Link
Lawson, A., H. Anderson and G. C. Schoenwolf. 2001. Cellular mechanisms of neural fold formation and morphogenesis in the chick embryo. Anat. Rec. 262: 153–168.
PubMed Link
Lee, S.-K. and S. L. Pfaff. 2001. Transcriptional networks regulating neuronal identity in the developing spinal cord. Nature Neurosci. Suppl. 4: 1183–1191.
PubMed Link
Lele, Z. and 8 others. 2002. Parachute/N-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube. Development 129: 3281–3294.
PubMed Link
Liem, K. F., Jr, T. M. Jessell and J. Briscoe. 2000. Regulation of the neural patterning activity of Sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites. Development 127: 4855–4866.
PubMed Link
Liem, K. F., Jr., G. Tremml and T. M. Jessell. 1997. A role for the roof plate and its resident TGF-b-related proteins in neuronal patterning in the dorsal spinal cord. Cell 91: 127–138.
PubMed Link
Liem, K. F., Jr., G. Tremml, H. Roelink and T. M. Jessell. 1995. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 82: 969–979.
PubMed Link
Lowery, L. A. and H. Sive. 2004. Strategies of neurulation and a re-evaluation of teleost neural tube formation. Mech. Dev. 121: 1189–1197.
PubMed Link
Lumsden, A. 2004. Segmentation and compartition in the early avian hindbrain. Mech. Dev. 121: 1081–1088.
PubMed Link
Massarwa, R. and L. Niswander. 2013. In toto live imaging of mouse morphogenesis and new insights into neural tube closure. Development 140: 226–236.
PubMed Link
McShane, S. G., M. A. Molè, D. Savery, N. D. Greene, P. P. Tam, and A. J. Copp. 2015. Cellular basis of neuroepithelial bending during mouse spinal neural tube closure. Dev. Biol. 404: 113–124.
PubMed Link
Milunsky, A., H. Jick, S. S. Jick, C. L. Bruell, D. S. Maclaughlen, K. J. Rothman and W. Willett. 1989. Multivitamin folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. J. Am. Med. Assoc. 262: 2847–2852.
PubMed Link
Moore, K. L. and T. V. N. Persaud. 1993. Before We Are Born: Essentials of Embryology and Birth Defects. W. B. Saunders, Philadelphia.
Moury, J. D. and G. C. Schoenwolf. 1995. Cooperative model of epithelial shaping and bending during avian neurulation: Autonomous movements of the neural plate, autonomous movements of the epidermis, and interactions in the neural plate/epidermis transition zone. Dev. Dynam. 204: 323–337.
PubMed Link
Muhr, J., E. Andersson, M. Persson, T. M. Jessell and J. Ericson. 2001. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral spinal cord. Cell 104: 861–873.
PubMed Link
Murko, C., S. Lagger, M. Steiner, C. Seiser, C. Schoefer, and O. Pusch. 2013. Histone deacetylase inhibitor trichostatin A induces neural tube defects and promotes neural crest specification in the chicken neural tube. Differentiation 85: 55–66.
PubMed Link
Nakatsu, T., C. Uwabe and K. Shiota. 2000. Neural tube closure in humans initiates at multiple sites: Evidence from human embryos and implications for the pathogenesis of neural tube defects. Anat. Embryol. 201: 455–466.
PubMed Link
Nguyen, V. H., J. Trout, S. A. Connors, P. Andermann, E. Weinberg and M. C. Mullins. 2000. Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway. Development 127:1209–1220.
PubMed Link
Nicol, D. and I. A. Meinertzhagen. 1988a. Development of the central nervous system of the larva of the ascidian Ciona intestinalis L. I. The early lineages of the neural plate. Dev. Biol. 130: 721–736.
PubMed Link
Nicol, D. and I. A. Meinertzhagen. 1988b. Development of the central nervous system of the larva of the ascidian Ciona intestinalis L. II. Neural plate morphogenesis and cell lineages during neurulation. Dev. Biol. 130: 737–766.
PubMed Link
Nievelstein, R. A. J., N. G. Hartwig, C. Vermeij-Keers and J. Valk. 1993. Embryonic development of the mammalian caudal neural tube. Teratology 48: 21–31.
PubMed Link
Niwa, M. and 10 others. 2013. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science 339: 335–339.
PubMed Link
O’Rahilly, R. and F. Müller. 2002. The two sites of fusion of the neural folds and the two neuropores of the human embryo. Teratology 65: 162–170.
PubMed Link
Pasteels, J. 1937. Etudes sur la gastrulation des vertébrés méroblastiques. III. Oiseaux. IV. Conclusions générales. Arch. Biol. 48: 381–488.
Patten, B. M. 1971. Early Embryology of the Chick, 5th Ed. McGraw-Hill, New York.
Placzek, M., M. Tessier-Lavigne, T. Yamada, T. Jessell and J. Dodd. 1990. Mesodermal control of neural cell identity: Floor plate induction by the notochord. Science 250: 985–988.
PubMed Link
Pyrgaki, C., A. Liu, and L. Niswander. 2011. Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev Biol. 353: 38–49.
PubMed Link
Pyrgaki, C., P. Trainor, A. K. Hadjantonakis and L. Niswander. 2010. Dynamic imaging of mammalian neural tube closure. Dev. Biol. 344: 941–947.
PubMed Link
Rifat, Y. and 7 others. 2010. Regional neural tube closure defined by the Grainy head-like transcription factors. Dev. Biol. 345: 237–245.
PubMed Link
Roelink, H., J. A. Porter, C. Chiang, Y. Tanabe, D. T. Chang, P. A. Beachy and T. M. Jessell. 1995. Floor plate and motor neuron induction by different concentrations of amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81: 445–455.
PubMed Link
Saitsu, H., S. Yamada, C. Uwabe, M. Ishibashi and K. Shiota. 2007. Aberrant differentiation of the axially condensed tail bud mesenchyme in human embryos with lumbosacral myeloschisis. Anat. Rec. (Hoboken) 290: 251–258.
PubMed Link
Sasai, N., E. Kutejova, and J. Briscoe. 2014. Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity. PLoS Biol. 12: e1001907.
PubMed Link
Sausedo, R. A., J. L. Smith and G. C. Schoenwolf. 1997. Role of oriented cell division in shaping and bending of the neural plate. J. Comp. Neurol. 381: 473–488.
PubMed Link
Schoenwolf, G. C. 1984. Histological and ultrastructural studies of secondary neurulation in mouse embryos. Am. J. Anat. 169: 361–376.
PubMed Link
Schoenwolf, G. C. 1991a. Cell movements driving neurulation in avian embryos.Development 2 [Suppl.]: 157–168.
PubMed Link
Schoenwolf, G. C. 1991b. Cell movements in the epiblast during gastrulation and neurulation in avian embryos. In R. Keller et al. (eds)., Gastrulation. Plenum, New York, pp. 1–28.
Schoenwolf, G. C. and M. V. Franks. 1984. Quantitative analyses of changes in cell shapes during bending of the avian neural plate. Dev. Biol. 105: 257–272.
PubMed Link
Schoenwolf, G. C. and J. Delongo. 1980. Ultrastructure of secondary neurulation in the chick embryo. Amer. J. Anat. 158: 43–63.
PubMed Link
Schoenwolf, G. C. and J. L. Smith. 1990. Epithelial cell wedging: A fundamental cell behavior contributing to hinge point formation during epithelial morphogenesis. In R. E. Keller and D. Fristrom (eds.). Control of Morphogenesis, Vol. 1. London: Saunders, pp. 325–334.
Shimokita, E., I. Kashin and Y. Takahashi. 2010. Secondary neurulation: A novel model to study tubulogenesis. Poster presentation.
Shpargel, K. B., T. Sengoku, S. Yokoyama, and T. Magnuson. 2012. UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLoS Genet. 8: e1002964.
PubMed Link
Shyamasundar, S., S. P. Jadhav, B. H. Bay, S. S. W. Tay, S. D. Kumar, D. Rangasamy, and S. T. Thameem Dheen. 2013. Analysis of epigenetic factors
in mouse embryonic neural stem cells exposed to hyperglycemia. PLoS One 8: e65945.
PubMed Link
Smith, J. L. and G. C. Schoenwolf. 1987. Cell cycle and neuroepithelial cell shape during bending of the chick neural plate. Anat. Rec. 218: 196–206.
PubMed Link
Smith, J. L. and G. C. Schoenwolf. 1988. Role of cell cycle in regulating neuroepithelial cell shape during bending of the chick neural plate. Cell Tissue Res. 252: 491–500.
PubMed Link
Smith, J. L. and G. C. Schoenwolf. 1989. Notochordal induction of cell wedging in the chick neural plate and its role in neural tube formation. J. Exp. Zool. 250: 49–62.
PubMed Link
Smith, J. L. and G. C. Schoenwolf. 1991. Further evidence of extrinsic forces in bending of the neural plate. J. Comp. Neurol. 307: 225–236.
PubMed Link
Smith, J. L. and G. C. Schoenwolf. 1997. Neurulation: Coming to closure. Trends Neurosci. 20: 510–517.
PubMed Link
Stern, C. D. 2005. Neural induction: Old problem, new findings, yet more questions. Development 132: 2007–2021.
PubMed Link
Stottmann, R. W., M. Berrong, K. Matta, M. Choi, and J. Klingensmith. 2006. The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. Dev. Biol. 295: 647–663.
PubMed Link
Takemoto, T. and 6 others. 2011. Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature 470: 394–398.
PubMed Link
Tye, K. M. and 12 others. 2013. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature 493: 537–541.
PubMed Link
Tzouanacou, E., A. Wegener, F. J. Wymeersch, V. Wilson and J. F. Nicolas. 2009. Defining the progression of lineage segregations during mammalian embryogenesis by clonal analysis. Dev. Cell 17: 365–376.
PubMed Link
van Straaten, H. W. M., J. W. M. Hekking, E. J. L. M. Wiertz-Hoessels, F. Thors and J. Drukker. 1988. Effect of the notochord on the differentiation of a floor plate area in the neural tube of the chick embryo. Anat. Embryol. 177: 317–324.
PubMed Link
Welstead, G. G., M. P. Creyghton, S. Bilodeau, A. W. Cheng, S. Markoulaki, R. A. Young, and R. Jaenisch. 2012. X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner. Proc. Natl. Acad. Sci. 109: 13004–13009.
PubMed Link
Werth, M. and 13 others. 2010. The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex. Development 137: 3835–3845.
PubMed Link
Wilde, J. J., J. R. Petersen, and L. Niswander. 2014. Genetic, epigenetic, and environmental contributions to neural tube closure. Annu. Rev. Genet. 48: 583–611.
PubMed Link
Wilson, S. I. and T. Edlund. 2001. Neural induction: Toward a unifying mechanism. Nature Neurosci. 4: 1161–1168.
PubMed Link
Wilson, V., I. Olivera-Martinez and K. G. Storey. 2009. Stem cells, signals and vertebrate body axis extension. Development 136:1591–1604.
PubMed Link
Xiong, F. and 11 others. 2013. Specified neural progenitors sort to form sharp domains after noisy Shh signaling. Cell 153: 550-561.
PubMed Link
Ybot-Gonzalez, P., C. Gaston-Massuet, G. Girdler, J. Klingensmith, R. Arkell, N. D. E. Greene, and A. J. Copp. 2007. Neural plate morphogenesis during mouse neurulation is regulated by antagonism of BMP signalling. Development 134: 3203–3211.
PubMed Link
Ybot-Gonzalez, P., P. Cogram, D. Gerrelli, and A. J. Copp. 2002. Sonic hedgehog and the molecular regulation of mouse neural tube closure. Development 129: 2507–2517.
PubMed Link