Ένα από τα ελάχιστα επιστημονικά πεδία στα οποία η χώρα μας εμφανίζει αξιοσημείωτη παράδοση είναι ο χώρος των συνθετικών βιοδραστικών πεπτιδίων, δηλαδή ενώσεων οι οποίες εμφανίζουν δράση ορμονική, νευροδιαβιβαστού, αντιβιοτική κ.ά και βρίσκουν μεγάλη φαρμακολογική και κλινική εφαρμογή. Στον τόμο αυτό συγκεντρώθηκαν 22 άρθρα από τα πρακτικά του 1ου ελληνικού Forum για τα βιοδραστικά πεπτίδια που έγινε στην Πάτρα το 1996, με σκοπό τη διάχυση των αποτελεσμάτων της έρευνας Eλλήνων επιστημόνων και των συνεργαζόμενων με αυτούς συναδέλφων της αλλοδαπής, πάνω σε θέματα αιχμής σχετικά με τα βιοδραστικά πεπτίδια.
On October 14th 1996, peptide scientists from Hellenic Universities and Research Institutes gathered at the University of Patras to participate in the 1st Hellenic Forum on Bioactive Peptides. The purpose of this assembly was to promote already established research collaboration with other well-known groups working on related disciplines, and at the same time to make known further the human endeavor in research by Hellenic scientists collaborating with fellow reseachers from abroad in the field of peptides, which in Hellas has been considerably developed since the time of Professor Leonidas Zervas. The gathering was dedicated to Professor Dimitrios Theodoropoulos on his seventieth birthday. The present commemorative volume contains the proceedings of the opening and scientific session of the Forum, as well as contributions of former students, co-workers and friends of Dimitrios Theodoropoulos, describing some of their work or reviewing the advancements in specific areas of peptide research.
ΠΕΡΙΕΧΟΜΕΝΑ
OPENING OF THE FORUM
Welcoming addresses
Paul Cordopatis, A Brief Account of an Inventive Career; A Tribute to Dimitrios Theodoropoulos
Dimitrios Theodoropoulos, A Historical Account of the Development of the University of Patras
SCIENTIFIC CONTRIBUTIONS
Rei Matsueda, The Concept of “Protection and Activation” of Functional Groups in Peptide Chemistry
Dionissios A. Papaioannou, Syntheses of Biologically Interesting Compounds Using N–Tritylamino Acids
George Kokotos, Violetta Constantinou–Kokotou and William A. Gibbons, Synthesis and Biological Activity of Lipidic α–Amino Acids, Lipidic Peptides and Lipid Mimetics
Fernando Filira, Laura Biondi, Marina Gobbo, Flavio Maran and Raniero Rocchi, Synthesis of Nβ–Substituted Derivatives of 2,3–Diaminopropenoic acid (β–Amino–α,β–didehydroalanine) and 2,3–Diamino–DL–propanoic acid (β–Amino–DL–alanine)
Violetta Constantinou–Kokotou, Stamatia Kotretsou and Marie–Paul Mingeot–Leclercq, Amino Acid and Peptide Derivatives of Aminocyclitols: An Approach to Less Toxic Antibiotics
Vincent Dive, Jirυi Jiracek and Athanasios Yiotakis, Phosphinic Pseudopeptide Libraries
Ulf Ragnarsson, The Substrate Specificity of cAMP–dependent Protein Kinase. A New Look at Old Data
Yannis D. Clonis, Peptide Affinity Ligands in Protein Purification Technology
Manolis Tiliakos, Catherine P. Raptopoulou, Alexandros Tsohos, Aris Terzis, Spyros P. Perlepes, Paul Cordopatis and Evy Manessi–Zoupa, Copper (II) Complexes of Dipeptides Containing α–Aminoisobutyric Acid
Ioannis P. Gerothanassis, Charalambos G. Kalodimos and Michel Momenteau, Multinuclear NMR Studies of Hemoproteins and Synthetic Model Compounds in Solution and in the Solid State
Graham J. Moore and John M. Matsoukas, Charge Transfer Interactions in Peptide Hormones
Richard Bouley, Hendrick Plante, Jacqueline Perodin, Lenka Maletinska, Lenka Rihakova, Mylene Gosselin and Emanuel Escher, Comparative Structure–Activity Study on Mammal and Fowl Angiotensin II Receptors
Gotfryd Kupryszewski and Krzysztof Rolka, Cucurbita maxima Trypsin Inhibitors I and III (CMT–I and CMT–III). Structure– Activity Relationship Studies
Jirina Slaninova, Miroslava Zertova, Zdenko Prochazka, Effect of Tyrosinamide9 Substitution in Agonists and Antagonists of Oxytocin and Oxypressin
George Stavropoulos, Vassiliki Magafa and Costas Karagiannis, Synthesis of Potent Agonists of Substance P by Replacement of Met11 with Asp(OR) Esters of Several C–terminal Peptide Fragments
Anna Tsapara and Christos Stournaras, Substitutions of Actin in Position 374: A Model to Study the Regulatory Role of Actin Polymerization Dynamics in Non–muscle Cells,
Jacqueline Perodin, Stephane A. Laporte, Stephanie Roy, Richard Leduc and Emanuel Escher, The Pharmacology of Angiotensin II and its Analogues: Correlation Between Bioassays of Animal Origin and the Human Angiotensin II Receptor,
Achille Gravanis, Emmanuel Zoumakis, Antonis Makrigiannakis, Christos Stournaras and Andrew N. Margioris, Molecular Pharmacology of Endometrial Neuropeptides: Corticotropin–Releasing Hormone (CRH) and Opioid Peptides
Dimitri Monos, Christodoulos Floudas and Paul Cordopatis, HLA–Peptide Interactions: Theoretical and Experimental Approaches
Sophie Tourdot, Mohamed Oukka, Jean Claude Manuguerra, George N. Pairas, Paul Cordopatis and Kostas Kosmatopoulos, Protection Against Lethal Viral Infection by Vaccination with Modified Subdominant Peptides
Angeliki Roboti, Irene Vassiliadou, Leondios Leondiadis, Evangelia Livaniou, Nikolas Ferderigos and Dionyssis S. Ithakissios, Development of Specific Anti–peptide Antisera for Human Beta Thymosins
Maria Sakarellos–Daitsiotis, Vassilios Tsikaris, Constantinos Sakarellos, Manh Thong Cung, Michel Marraud, Socrates Tzartos, Ketty Soteriadou, Panayiotis G. Vlachogiannopoulos and Haralampos M. Moutsopoulos, Carriers of Peptide Epitopes for the Development of Specific Diagnostic Immunoassays and Protective Immunity
Paul Cordopatis, A Brief Account of an Inventive Career; A Tribute to Dimitrios Theodoropoulos
Dimitrios Theodoropoulos, A Historical Account of the Development of the University of Patras
SCIENTIFIC CONTRIBUTIONS
Rei Matsueda, The Concept of “Protection and Activation” of Functional Groups in Peptide Chemistry
Dionissios A. Papaioannou, Syntheses of Biologically Interesting Compounds Using N–Tritylamino Acids
George Kokotos, Violetta Constantinou–Kokotou and William A. Gibbons, Synthesis and Biological Activity of Lipidic α–Amino Acids, Lipidic Peptides and Lipid Mimetics
Fernando Filira, Laura Biondi, Marina Gobbo, Flavio Maran and Raniero Rocchi, Synthesis of Nβ–Substituted Derivatives of 2,3–Diaminopropenoic acid (β–Amino–α,β–didehydroalanine) and 2,3–Diamino–DL–propanoic acid (β–Amino–DL–alanine)
Violetta Constantinou–Kokotou, Stamatia Kotretsou and Marie–Paul Mingeot–Leclercq, Amino Acid and Peptide Derivatives of Aminocyclitols: An Approach to Less Toxic Antibiotics
Vincent Dive, Jirυi Jiracek and Athanasios Yiotakis, Phosphinic Pseudopeptide Libraries
Ulf Ragnarsson, The Substrate Specificity of cAMP–dependent Protein Kinase. A New Look at Old Data
Yannis D. Clonis, Peptide Affinity Ligands in Protein Purification Technology
Manolis Tiliakos, Catherine P. Raptopoulou, Alexandros Tsohos, Aris Terzis, Spyros P. Perlepes, Paul Cordopatis and Evy Manessi–Zoupa, Copper (II) Complexes of Dipeptides Containing α–Aminoisobutyric Acid
Ioannis P. Gerothanassis, Charalambos G. Kalodimos and Michel Momenteau, Multinuclear NMR Studies of Hemoproteins and Synthetic Model Compounds in Solution and in the Solid State
Graham J. Moore and John M. Matsoukas, Charge Transfer Interactions in Peptide Hormones
Richard Bouley, Hendrick Plante, Jacqueline Perodin, Lenka Maletinska, Lenka Rihakova, Mylene Gosselin and Emanuel Escher, Comparative Structure–Activity Study on Mammal and Fowl Angiotensin II Receptors
Gotfryd Kupryszewski and Krzysztof Rolka, Cucurbita maxima Trypsin Inhibitors I and III (CMT–I and CMT–III). Structure– Activity Relationship Studies
Jirina Slaninova, Miroslava Zertova, Zdenko Prochazka, Effect of Tyrosinamide9 Substitution in Agonists and Antagonists of Oxytocin and Oxypressin
George Stavropoulos, Vassiliki Magafa and Costas Karagiannis, Synthesis of Potent Agonists of Substance P by Replacement of Met11 with Asp(OR) Esters of Several C–terminal Peptide Fragments
Anna Tsapara and Christos Stournaras, Substitutions of Actin in Position 374: A Model to Study the Regulatory Role of Actin Polymerization Dynamics in Non–muscle Cells,
Jacqueline Perodin, Stephane A. Laporte, Stephanie Roy, Richard Leduc and Emanuel Escher, The Pharmacology of Angiotensin II and its Analogues: Correlation Between Bioassays of Animal Origin and the Human Angiotensin II Receptor,
Achille Gravanis, Emmanuel Zoumakis, Antonis Makrigiannakis, Christos Stournaras and Andrew N. Margioris, Molecular Pharmacology of Endometrial Neuropeptides: Corticotropin–Releasing Hormone (CRH) and Opioid Peptides
Dimitri Monos, Christodoulos Floudas and Paul Cordopatis, HLA–Peptide Interactions: Theoretical and Experimental Approaches
Sophie Tourdot, Mohamed Oukka, Jean Claude Manuguerra, George N. Pairas, Paul Cordopatis and Kostas Kosmatopoulos, Protection Against Lethal Viral Infection by Vaccination with Modified Subdominant Peptides
Angeliki Roboti, Irene Vassiliadou, Leondios Leondiadis, Evangelia Livaniou, Nikolas Ferderigos and Dionyssis S. Ithakissios, Development of Specific Anti–peptide Antisera for Human Beta Thymosins
Maria Sakarellos–Daitsiotis, Vassilios Tsikaris, Constantinos Sakarellos, Manh Thong Cung, Michel Marraud, Socrates Tzartos, Ketty Soteriadou, Panayiotis G. Vlachogiannopoulos and Haralampos M. Moutsopoulos, Carriers of Peptide Epitopes for the Development of Specific Diagnostic Immunoassays and Protective Immunity
